Quality and stability of topical formulation based on the extract of black locust flower (Robiniae pseudoacaciae flos)
Abstract
Black locust flowers are the source of a significant amount of antioxidants that can be useful against free radicals formed on the skin after the environmental factors. Having in mind these facts, the ultrasound-assisted extraction of antioxidants from plant materials was previously developed. The aim of this study was to prepare a topical formulation based on the extract of black locust flowers. The extract enriched with antioxidants was prepared using the ultrasound-assisted extraction using 60% (v/v) ethanol at 60 °C and a liquid-to-solid ratio of 10 mL/g for 30 min. The two topical formulations in the form of o/w emulsion at different concentrations of the extract (1% and 2%) were prepared by a hot-hot emulsification process. The product quality was estimated and concluded that the emulsion is white in the semi-solid state. The formulations can have adequate application properties due to their present ingredients, which do not leave a greasy film on the skin. The pH value of the prepared formulations was according to the allowed range for the application to the skin. The proper choice of ingredients enabled the achievement of satisfactory formulation stability. The formulations can be microbiologically safe to use for human purposes. A better antimicrobial activity against the investigated microorganism strains showed the formulation with higher content of the extract so it can be selected as an adequate for further analysis.
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Akhtar, N., Khan, B. A., Haji, M., Khan, S., Ahmad, M., Rasool, F., Mahmood, T.,Rasul, A. 2011: Evaluation of various functional skin parameters using a topical cream of Calendula officinalis extract. African Journal of Pharmacy and Pharmacology, 5(2): 199-206.
Baumann, L. 2011: Kozmetička dermatologija: načela i praksa. Prvo izdanje na hrvatskom jeziku. Interpreta usluge d.o.o., Zagreb.
Bhalla, P., Bajpai, V.K. 2017: Chemical composition and antibacterial action of Robinia pseudoacacia L. flower essential oil on membrane permeability of foodborne pathogens. Journal of Essential Oil Bearing Plants, 20(3): 632-645.
Chen, S., Han, Y., Jian, L., Liao, W., Zhang, Y., Gao, Y. 2020: Fabrication, characterization, physicochemical stability of zein-chitosan nanocomplex for co-encapsulating curcumin and resveratrol. Carbohydrate Polymers, 236: 116090.
Choulitoudi, E., Xristou, M., Tsimogiannis, D., Oreopoulou, V. 2021: The effect of temperature on the phenolic content and oxidative stability of o/w emulsions enriched with natural extracts from Satureja thymbra. Food Chemistry, 349: 129206.
de Lima Cherubim, D.J., Buzanello Martins, C.V., Oliveira Fariña, L., da Silva de Lucca, R.A. 2020: Polyphenols as natural antioxidants in cosmetics applications. Journal of Cosmetic Dermatology, 19(1): 33-37.
Deng, J., Yang, H., Capanoglu, E., Cao, H., Xiao, J. 2018: Technological aspects and stability of polyphenols. In: Polyphenols: Properties, recovery, and applications: 295-323, Woodhead Publishing.
Dzah, C.S., Duan, Y., Zhang, H., Wen, C., Zhang, J., Chen, G., Ma, H. 2020: The effects of ultrasound assisted extraction on yield, antioxidant, anticancer and antimicrobial activity of polyphenol extracts: A review. Food Bioscience, 35: 100547.
Farjadmand, F., Karimpour-Razkenari, E., Nabavi, S.M., Ardekani, M.R., Saeedi, M. 2021: Plant polyphenols: Natural and potent UV-protective agents for the prevention and treatment of skin disorders. Mini Reviews in Medicinal Chemistry, 21(5): 576-585.
Figueroa-Robles, A., Antunes-Ricardo, M., Guajardo-Flores, D. 2020: Encapsulation of phenolic compounds with liposomal improvement in the cosmetic industry. International Journal of Pharmaceutics, 120125.
Garcia, D.E., Glasser, W.G., Pizzi, A., Paczkowski, S.P., Laborie, M.P. 2016: Modification of condensed tannins: from polyphenol chemistry to materials engineering. New Journal of Chemistry, 40(1): 36-49.
Golonka, I., Wilk, S., Musiał, W. 2020: The Influence of UV Radiation on the degradation of pharmaceutical formulations containing quercetin. Molecules, 25(22): 5454.
Guimarães, I., Baptista-Silva, S., Pintado, M., L Oliveira, A. 2021: Polyphenols: A promising avenue in therapeutic solutions for wound care. Applied Sciences, 11(3): 1230.
https://www.paragraf.rs/propisi/pravilnik-uslovima-pogledu-zdravstvene-ispravnosti-predmeta-opste-upotrebe.html
ICH Q1A (R2) Stability testing of new drug substances and drug products, European Medicines Agency, Netherlands.
Jee, J.P., Pangeni, R., Jha, S.K., Byun, Y., Park, J.W. 2019: Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin, and oxygen carriers for enhanced diabetic wound-healing therapy. International Journal of Nanomedicine, 14: 5449.
Jiang, J., Mei, Z., Xu, J., Sun, D. 2013: Effect of inorganic electrolytes on the formation and the stability of water-in-oil (W/O) emulsions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 429: 82-90.
Juttulapa, M., Piriyaprasarth, S., Takeuchi, H., Sriamornsak, P. 2017: Effect of high-pressure homogenization on stability of emulsions containing zein and pectin. Asian Journal of Pharmaceutical Sciences, 12(1): 21-27.
Katsouli, M., Polychniatou, V., Tzia, C. 2017: Influence of surface-active phenolic acids and aqueous phase ratio on w/o nano-emulsions properties; model fitting and prediction of nano-emulsions oxidation stability. Journal of Food Engineering, 214: 40-46.
Lambers, H., Piessens, S., Bloem, A., Pronk, H., Finkel, P. 2006: Natural skin surface pH is on average below 5, which is beneficial for its resident flora. International Journal of Cosmetic Science, 28(5): 359-370.
Latva-Mäenpää, H., Wufu, R., Mulat, D., Sarjala, T., Saranpää, P., Wähälä, K. 2021: Stability and photoisomerization of stilbenes isolated from the bark of Norway spruce roots. Molecules, 26(4): 1036.
Leite, F.D.G., Oshiro Júnior, J.A., Chiavacci, L.A., Chiari-Andréo, B.G. 2019: Assessment of an anti-ageing structured cosmetic formulation containing goji berry. Brazilian Journal of Pharmaceutical Sciences, 55.
Li, R., Peng, S., Zhang, R., Dai, T., Fu, G., Wan, Y., Liu, C., McClements, D.J. 2019: Formation and characterization of oil-in-water emulsions stabilized by polyphenol-polysaccharide complexes: Tannic acid and β-glucan. Food Research International, 123: 266-275.
Madan, K., Nanda, S. 2018: In-vitro evaluation of antioxidant, anti-elastase, anti-collagenase, anti-hyaluronidase activities of safranal and determination of its sun protection factor in skin photoaging. Bioorganic Chemistry, 77: 159-167.
Maia Filho, D.C., Ramalho, J.B., Spinelli, L.S., Lucas, E.F. 2012: Aging of water-in-crude oil emulsions: Effect on water content, droplet size distribution, dynamic viscosity and stability. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 396: 208-212.
Ph. Jug. IV. 1984: Farmakopeja SFRJ, Pharmacopoea Jugoslavica, Savezni zavod za zdravstvenu zaštitu. Beograd.
Rosu, A.F., Bita, A., Calina, D., Rosu, L., Zlatian, O., Calina, V. 2012: Synergic antifungal and antibacterial activity of alcoholic extract of the species Robinia pseudoacacia L. (Fabaceae). European Journal of Hospital Pharmacy: Science and Practice, 19(2): 216-216.
Savic Gajic, I., Savic, I., Boskov, I., Žerajić, S., Markovic, I., Gajic, D. 2019: Optimization of ultrasound-assisted extraction of phenolic compounds from black locust (Robiniae pseudoacaciae) flowers and comparison with conventional methods. Antioxidants, 8(8): 248.
Shin, H.J., Beak, H.S., Kim, S.I., Joo, Y.H., Choi, J. 2018: Development and evaluation of topical formulations for a novel skin whitening agent (AP736) using Hansen solubility parameters and PEG-PCL polymers. International Journal of Pharmaceutics, 552(1-2): 251-257.
Smaoui, S., Hlima, H.B., Jarraya, R., Kamoun, N.G., Ellouze, R., Damak, M. 2012: Cosmetic emulsion from virgin olive oil: Formulation and bio-physical evaluation. African Journal of Biotechnology, 11(40): 9664-9671.
Souto, E.B., Sampaio, A.C., Campos, J.R., Martins-Gomes, C., Aires, A., Silva, A.M. 2019: Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems. Studies in Natural Products Chemistry, 63: 21-42.
Srivastava, J.K., Gupta, S. 2009: Extraction, characterization, stability and biological activity of flavonoids isolated from chamomile flowers. Molecular and Cellular Pharmacology, 1(3): 138-153.
Stojiljković, D., Arsić, I., Kostov, M.T., Jovanović, Z., Tadić, V., Ðorđević, S. 2013: Investigation of the effects of different emollients on the structure and skin moisturizing potential of the cosmetic creams. Acta Facultatis Medicae Naissensis, 30(4): 193-200.
Tsali, A., Goula, A.M. 2018: Valorization of grape pomace: Encapsulation and storage stability of its phenolic extract. Powder Technology, 340: 194-207.
Veiga, M., Costa, E.M., Silva, S., Pintado, M. 2020: Impact of plant extracts upon human health: A review. Critical Reviews in Food Science and Nutrition, 60(5): 873-886.
Wei, L.I., Zhang, Y. 2008: The antioxidation effect of Pyracantha fortuneana polyphenol in vitro. Science and Technology of Food Industry, 29(9): 121–123.
Yang, S., Liu, L., Han, J., Tang, Y. 2020: Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques. International Journal of Cosmetic Science, 42(1): 16-28.
Yuann, J.M.P., Lee, S.Y., Yang, M.J., Huang, S.T., Cheng, C.W., Liang, J.Y. 2021: A study of catechin photostability using photolytic processing. Processes, 9(2): 293.
Zillich, O.V., Schweiggert-Weisz, U., Hasenkopf, K., Eisner, P., Kerscher, M. 2013: Release and in vitro skin permeation of polyphenols from cosmetic emulsions. International Journal of Cosmetic Science, 35(5): 491-501.
Zillich, O.V., Schweiggert-Weisz, U., Eisner, P., Kerscher, M. 2015: Polyphenols as active ingredients for cosmetic products. International Journal of Cosmetic Science, 37(5): 455-464.
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