The pathophysiology of depression: its relation to inflammation, lipid peroxidation, and hypothalamic-pituitary-Adrenal axis dysregulation.

Ghania Mellal, Nacera Haroun, Khadidja Aiouez, Rachida Raache, DOI: 10.46793/BiolNyss.17.1.7M

Abstract


Depression is a complex multifactorial pathology and the most common mental illness. In this study we sought to determine the link between the deregulation of the hypothalamic-pituitary-adrenal axis, immuno-inflammatory markers, lipid peroxidation and depression. We included in our prospective study, 103 patients suffering from depressive episode and 50 controls. The hormonal status was evaluated by the measurement of adrenocorticotropic hormone (ACTH) and cortisol, the inflammatory status by nitric oxide (NO) and C-reactive protein (CRP), immune status by IgA IgG, IgM, and finally lipid peroxidation by estimating the level of malondialdehyde (MDA). Our results show a significant difference between the plasma level of the cortisol in depressed patients and controls  as well as for ACTH levels. In addition the mean levels of CRP  and MDA  in patients were significantly higher in patients in comparison to controls. These results  were correlated with the severity of depression.


Keywords


Depression; ACTH; Cortisol; Inflammation; lipid peroxidation

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References


Anisman, H., Zacharko, R. M. (1992). Depression as a consequence of inadequate neurochemical adaptation in response to stressors. The British Journal of Psychiatry, 160(S15), 36-43. DOI: https://doi.org/10.1192/S0007125000296669

Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., da Cruz Almeida, W. L., Rescia, V. C., & al. (2019). Molecular aspects of depression: a review from neurobiology to treatment. European journal of pharmacology, 851, 99-121. DOI: 10.1016/j.ejphar.2019.02.024

Bonaccorso, S., Marino, V., Biondi, M., Grimaldi, F., Ippoliti, F., Maes, M. (2002). Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus. Journal of affective disorders, 72(3), 237-241. • DOI: 10.1016/s0165-0327(02)00264-1

Camkurt, M. A., Fındıklı, E., Bakacak, M., Tolun, F. İ., Karaaslan, M. F. (2017). Evaluation of malondialdehyde, superoxide dismutase and catalase activity in fetal cord blood of depressed mothers. Clinical Psychopharmacology and Neuroscience, 15(1), 35. DOI: 10.9758/cpn.2017.15.1.35

Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., Dantzer, R. (2002). Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Molecular psychiatry, 7(5), 468-473. • DOI: 10.1038/sj.mp.4000995

Carroll, J. C., Boyce-Rustay, J. M., Millstein, R., Yang, R., Wiedholz, L. M., Murphy, D. L., & al. (2007). Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice. Behavior genetics, 37, 214-222. • DOI: 10.1007/s10519-006-9129-9

Choi, K. W., Na, E. J., Fava, M., Mischoulon, D., Cho, H., Jeon, H. J. (2018). Increased adrenocorticotropic hormone (ACTH) levels predict severity of depression after six months of follow-up in outpatients with major depressive disorder. Psychiatry research, 270, 246-252. • DOI: 10.1016/j.psychres.2018.09.047

Crocker, J., Park, L. E. (2004). The costly pursuit of self-esteem. Psychological bulletin, 130(3), 392. • DOI: 10.1037/0033-2909.130.3.392

Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of general psychiatry, 65(4), 409-415. • DOI: 10.1001/archpsyc.65.4.409

Del Rio, D., Stewart, A. J., Pellegrini, N. (2005). A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutrition, metabolism and cardiovascular diseases, 15(4), 316-328. DOI: 10.1016/j.numecd.2005.05.003

Dhir, A., Kulkarni, S. K. (2011). Nitric oxide and major depression. Nitric oxide, 24(3), 125-131. DOI: 10.1016/j.niox.2011.02.002

Guintivano, J., Kaminsky, Z. A. (2016). Role of epigenetic factors in the development of mental illness throughout life. Neuroscience research, 102, 56-66. • DOI: 10.1016/j.neures.2014.08.003

Howren, M. B., Lamkin, D. M., Suls, J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic medicine, (2009). 71(2), 171-186. • DOI: 10.1097/PSY.0b013e3181907c1b

Insel, K. C., Moore, I. M., Vidrine, A. N., Montgomery, D. W. (2012). Biomarkers for cognitive aging part II: oxidative stress, cognitive assessments, and medication adherence. Biological research for nursing, 14(2), 133-138. DOI: 10.1177/1099800411406527

Janszky, I., Lekander, M., Blom, M., Georgiades, A., Ahnve, S. (2005). Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease. Brain, behavior, and immunity, 19(6), 555-563. • DOI: 10.1016/j.bbi.2005.01.001

Knott, A. B., Bossy-Wetzel, E. (2009). Nitric oxide in health and disease of the nervous system. Antioxidants & redox signaling, 11(3), 541-553. DOI: 10.1089/ars.2008.2234

Kubzansky, L. D., Cole, S. R., Kawachi, I., Vokonas, P., Sparrow, D. (2006). Shared and unique contributions of anger, anxiety, and depression to coronary heart disease: a prospective study in the normative aging study. Annals of Behavioral Medicine, 31(1), 21-29. • DOI: 10.1207/s15324796abm3101_5

Lee, B. H., Lee, S. W., Yoon, D., Lee, H. J., Yang, J. C., Shim, S. H. (2006). Increased plasma nitric oxide metabolites in suicide attempters. Neuropsychobiology, 53(3), 127-132. • DOI: 10.1159/000092542

Lopez-Duran, N. L., Kovacs, M., George, C. J. (2009). Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology, 34(9), 1272-1283. • DOI: 10.1016/j.psyneuen.2009.03.016

Maes, M. (1995). Evidence for an immune response in major depression: a review and hypothesis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19(1), 11-38. DOI: 10.1016/0278-5846(94)00101-m

Maes, M., Galecki, P., Chang, Y. S., Berk, M. (2011). A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(3), 676-692. • DOI: 10.1016/j.pnpbp.2010.05.004

Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G. (2009). The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metabolic brain disease, 24, 27-53. • DOI: 10.1007/s11011-008-9118-1

Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K., Gray, N. A., & al. (2003). Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biological psychiatry, 53(8), 707-742. • DOI: 10.1016/s0006-3223(03)00117-3

Miller, E. S., Hoxha, D., Pinheiro, E., Grobman, W. A., Wisner, K. L. (2019). The association of serum C-reactive protein with the occurrence and course of postpartum depression. Archives of women's mental health, 22, 129-132. • DOI: 10.1007/s00737-018-0841-2

Miller, G., Chen, E., Cole, S. W. (2009). Health psychology: Developing biologically plausible models linking the social world and physical health. Annual review of psychology, 60, 501-524. • DOI: 10.1146/annurev.psych.60.110707.163551

Mössner, R. A., Mikova, O. L., Koutsilieri, E. L., Saoud, M., Ehlis, A., Müller, N., & al. (2007). Recommandation sur les marqueurs biologiques: marqueurs biologiques dans la dépression. The World Journal of biological Psychiatry, 8(3), 141-174. • DOI: 10.1080/15622970701263303

Öngür, D., Price, J. L. (2000). The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cerebral cortex, 10(3), 206-219. • DOI: 10.1093/cercor/10.3.206

Patel, N. J., Chen, M. J., Russo-Neustadt, A. A. (2010). Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons. European journal of pharmacology, 633(1-3), 1-9. • DOI: 10.1016/j.ejphar.2010.01.012

Posener, J. A., DeBattista, C., Williams, G. H., Kraemer, H. C., Kalehzan, B. M., Schatzberg, A. F. (2000). 24-Hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression. Archives of general psychiatry, 57(8), 755-760. DOI: 10.1001/archpsyc.57.8.755

Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., Kirli, S. (2007). Major depressive disorder is accompanied with oxidative stress: short‐term antidepressant treatment does not alter oxidative–antioxidative systems. Human Psychopharmacology: Clinical and Experimental, 22(2), 67-73. • DOI: 10.1002/hup.829

Solomon, D. A., Keller, M. B., Leon, A. C., Mueller, T. I., Shea, M. T., Warshaw, M., & al. (1997). Recovery from major depression: a 10-year prospective follow-up across multiple episodes. Archives of general psychiatry, 54(11), 1001-1006. • DOI: 10.1001/archpsyc.1997.01830230033005

Stefanescu, C., Ciobica, A. (2012). The relevance of oxidative stress status in first episode and recurrent depression. Journal of affective disorders, 143(1-3), 34-38. • DOI: 10.1016/j.jad.2012.05.022

Tsuboi, H., Tatsumi, A., Yamamoto, K., Kobayashi, F., Shimoi, K., Kinae, N. (2006). Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants. Journal of affective disorders, 91(1), 63-70. • DOI: 10.1016/j.jad.2005.12.010

Wichers, M. C., Koek, G. H., Robaeys, G., Verkerk, R., Scharpe, S., Maes, M. J. M. P. (2005). IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Molecular psychiatry, 10(6), 538-544. • DOI: 10.1038/sj.mp.4001600


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