The association of vitamin D, VDBP and ferritin levels in Iraqi men with type 2 diabetes

Mohammed Jawad Kadhim, Süleyman Aşir, Amer Hasan, DOI: 10.46793/BiolNyss.16.2.11K

Abstract


This study examined the association between vitamin D, vitamin D binding protein (VDBP), and ferritin in Iraqi men with type 2 diabetes (T2D). A total of 120 participants, 60 diabetic patients and 60 healthy controls aged 30 years and older, matched for the normal body mass index. Glucose levels were significantly elevated in the diabetic group (P = 0.001), confirming impaired glycemic regulation. Liver function markers, including total serum bilirubin (TSB) and glutamate oxaloacetate transaminase (GOT), were also significantly higher (P = 0.015 and P = 0.009, respectively), suggesting hepatic dysfunction. Although vitamin D3 concentrations did not differ significantly, reduced vitamin D bioactivity may result from liver impairment and significantly lower VDBP levels in diabetic individuals (P = 0.001), compromising its transport to target tissues. No significant differences were found in ferritin and renal markers. These findings highlight the possible role of disrupted vitamin D metabolism—particularly in transport and activation—in the pathogenesis of T2D.


Keywords


vitamin D; vitamin D binding protein (VDBP); ferritin; type 2 diabetes

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References


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